FEATURES

FAMILY

RNA polymerase-binding protein RbpA family

DESCRIPTION

Also known as RBPA_MYCTU, rbpA. Binds to RNA polymerase (RNAP), stimulating and stabilizing the formation of stable RNAP promoter complexes up to 2-fold from principal sigma factor SigA-dependent but not alternative sigma factor SigF-dependent promoters. Increases the affinity of core RNAP for SigA, increasing the transcriptional activity of RNAP. Unlike the case in M.smegmatis or S.coelicolor, has no effect on rifampicin inhibition of transcription. Has no effect on E.coli RNAP. Oligomerizes at more than 3 uM; this requires the C-terminal 32 residues. Forms a complex with the RNAP catalytic core, specifically with the beta subunit (rpoB). Interacts with free SigB, probably as a 1:1 complex, and also with free SigA, probably via its sigma-2 domain.

EXTERNAL LINKS

rbpA

Structural Ligandability

Domains Chains

Distribution