FEATURES

FAMILY

DESCRIPTION

Also known as ADOK_MYCTU, adoK, cbhK. Catalyzes the phosphorylation of adenosine to adenosine monophosphate (AMP) (PubMed:14594827, PubMed:16511094). Can also catalyze the phosphorylation of the adenosine analog 2-methyladenosine (methyl-Ado) to methyl-AMP, the first step in the metabolism of this compound to an active form that displays antitubercular activity. Is not active on guanosine, inosine, deoxyadenosine, cytidine, uridine, or thymidine. Prefers dGTP and GTP to ATP as phosphate donors in vitro (PubMed:14594827). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

adoK

Mutations

Mutation(s) distribution

Mutations table