FEATURES

FAMILY

DESCRIPTION

Also known as HSAA_MYCTU, hsaA. Catalyzes the o-hydroxylation of 3-hydroxy-9, 10-secoandrosta-1, 3, 5(10)-triene-9, 17-dione (3-HSA) to 3, 4-dihydroxy-9, 10-secoandrosta-1, 3, 5(10)-triene-9, 17-dione (3, 4-DHSA) in the catabolism of cholesterol. Can also use 3, 17-dihydroxy-9, 10-seconandrost-1, 3, 5(10)-triene-9-one (3, 17-DHSA), but it has higher specificity for 3-HSA than for 3, 17-DHSA. Can use either FADH(2) or FMNH(2) as flavin cosubstrate. Also catalyzes the o-hydroxylation of a range of p-substituted phenols to generate the corresponding catechols. Homotetramer under anaerobic conditions. HsaAB monooxygenase consists of an oxygenase component HsaA and a reductase component HsaB.

EXTERNAL LINKS

hsaA

Flavin-dependent monooxygenase, oxygenase subunit HsaA

hsaA

Molecular Synopsis