FEATURES

FAMILY

DESCRIPTION

Also known as DPRE1_MYCTU, dprE1. Component of the DprE1-DprE2 complex that catalyzes the 2-step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans (PubMed:16291675, PubMed:19299584). DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX) (PubMed:22733761). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate channel' at the interface of DprE1-DprE2 complex (PubMed:25789990). Can also use farnesyl-phosphoryl-beta-D-ribofuranose (FPR) as substrate in vitro (PubMed:25427196). Appears to be essential for the growth and survival of M.tuberculosis (PubMed:12657046, PubMed:24517327)., DprE1 is a highly vulnerable and fully validated tuberculosis drug target. Monomer. Although forming apparent dimer in crystals, DprE1 does not dimerize appreciably in solution (PubMed:22733761). Interacts with DprE2 to form an epimerase complex (PubMed:25789990).

EXTERNAL LINKS

dprE1

Decaprenylphosphoryl-beta-D-ribose oxidase

dprE1

Molecular Synopsis