FEATURES

FAMILY

DESCRIPTION

Also known as BLAC_MYCTU, blaC, blaA. Extended spectrum beta-lactamase (ESBL) that inactivates beta-lactam antibiotics by hydrolyzing the amide group of the beta-lactam ring. Displays high levels of penicillinase and cephalosporinase activity as well as measurable activity with carbapenems, including imipenem and meropenem. Plays a primary role in the intrinsic resistance of M.tuberculosis to beta-lactam antibiotics. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

blaC

Structural Ligandability

Domains Chains

Distribution