FEATURES

FAMILY

F420H(2)-dependent biliverdin reductase family

DESCRIPTION

Also known as FBVR_MYCTU, MTCY49.13. Catalyzes the F420H(2)-dependent reduction of biliverdin-IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalpha is produced in high amounts in macrophages infected with M.tuberculosis, its reduction by Rv2074 may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of M.tuberculosis infection. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

MTCY49.13

F420H(2)-dependent biliverdin reductase

MTCY49.13

Molecular Synopsis