FEATURES

FAMILY

DESCRIPTION

Also known as GLN1B_MYCTO, glnA1, glnA. Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Also plays a key role in controlling the ammonia levels within infected host cells and so contributes to the pathogens capacity to inhibit phagosome acidification and phagosome-lysosome fusion. Involved in cell wall biosynthesis via the production of the major component poly-L-glutamine (PLG). PLG synthesis in the cell wall occurs only in nitrogen limiting conditions and on the contrary high nitrogen conditions inhibit PLG synthesis. Oligomer of 12 subunits arranged in the form of two hexagons.

EXTERNAL LINKS

uniprot
enzyme classification

glnA1

Glutamine synthetase

glnA1

Molecular Synopsis