FEATURES

DESCRIPTION

Also known as ECC1B_MYCTU, eccCb1, snm2. Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:14557547, PubMed:14557536, PubMed:16368961, PubMed:16973880). EccCb1 may link the cytosolic components of the system with the membrane components (PubMed:16973880). Part of the ESX-1 / type VII secretion system (T7SS), which is composed of cytosolic and membrane components. The ESX-1 membrane complex is composed of EccB1, EccCa1, EccCb1, EccD1 and EccE1 (PubMed:14557536, PubMed:16368961, PubMed:19876390). Interacts with EccCa1, EspK and the C-terminus of EsxB (PubMed:14557536, PubMed:16973880, PubMed:17676952). Residues 1-261 interact with EsxB and an artificial EsxB-EsxA heterodimer (PubMed:19854905).

EXTERNAL LINKS

eccCb1

Mutations

Mutation(s) distribution

Mutations table