FEATURES

FAMILY

DESCRIPTION

Also known as DPO3X_MYCTU, dnaX, dnaZX. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. Interacts with the beta sliding-clamp (dnaN) (PubMed:22545130). DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

dnaX

DNA polymerase III subunit gamma/tau

dnaX

Structural Ligandability

Domains Chains

Distribution