FEATURES

FAMILY

CDP-alcohol phosphatidyltransferase class-I family

DESCRIPTION

Also known as PIPS_MYCTU, pgsA1, pgsA. Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid for mycobacteria required for formation of their cell wall. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

pgsA1

Phosphatidylinositol phosphate synthase

pgsA1

Molecular Synopsis