FEATURES

FAMILY

DESCRIPTION

Also known as PTKA_MYCTU, ptkA. Required for growth within macrophages (PubMed:29317718). Catalyzes the phosphorylation of PtpA on the tyrosine residues at positions 128 and 129, thereby increasing PtpA phosphatase activity and promoting pathogenicity (PubMed:19366344, PubMed:22888002, PubMed:25535696, PubMed:29724125). Also phosphorylates the thioredoxin reductase TrxB (PubMed:29317718). Interacts with PtpA (PubMed:19366344, PubMed:22888002, PubMed:29724125). The presence of a phosphate donor increases the interaction affinity (PubMed:19366344). Interacts with TrxB (PubMed:29317718). Interacts with several eukaryotic-like Ser/Thr protein kinases (eSTPKs) in vivo, including PknA (PubMed:26417687).

EXTERNAL LINKS

ptkA

Tyrosine-protein kinase PtkA

ptkA

Molecular Synopsis