FEATURES

FAMILY

DESCRIPTION

Also known as CP124_MYCTU, cyp124. Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E, 6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E, 6E)-farnesyl diphosphate (PubMed:19933331). Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate (PubMed:20843794). Cyp124 catalyzes preferentially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer (PubMed:20843794). Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one (PubMed:20843794).

Also known as CP124_MYCTU, cyp124. Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E, 6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and ( ...

EXTERNAL LINKS

cyp124

Methyl-branched lipid omega-hydroxylase

cyp124

Molecular Synopsis