FEATURES

FAMILY

DESCRIPTION

Also known as BIOD_MYCTU, bioD. Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7, 8-diaminopelargonic acid (DAPA, also called 7, 8-diammoniononanoate) to form a ureido ring (PubMed:20565114). Can use a range of NTPs; has highest affinity for CTP (KD is measured as 17.2 uM or 0.160 uM in 2 different papers) while KD for ATP is 331 uM or 75 uM in the same papers. Gly-169 plays a role in NTP discrimination (PubMed:25801336, Ref.5). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

bioD

Dethiobiotin synthetase BioD

bioD

Molecular Synopsis