FEATURES

FAMILY

3-oxoacid CoA-transferase subunit B family

DESCRIPTION

Also known as IPDB_MYCTU, ipdB. Involved in the final steps of cholesterol and steroid degradation (PubMed:28377529). Opens the last steroid ring of cholesterol by catalyzing the hydrolysis of (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA (COCHEA-CoA) to 6-methyl-3, 7-dioxodecanedioyl-CoA (MeDODA-CoA) (PubMed:29581275). Heterotetramer composed of 2 IpdA subunits and 2 IpdB subunits.

EXTERNAL LINKS

uniprot
enzyme classification

ipdB

Cholesterol ring-cleaving hydrolase IpdB subunit

ipdB

Molecular Synopsis