FEATURES

FAMILY

DESCRIPTION

Also known as KASA_MYCTU, kasA. Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis. Catalyzes the elongation of long chain acyl-ACP substrates by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:11600501, PubMed:12023885, PubMed:12464486, PubMed:16873379, PubMed:22017312, PubMed:24108128). Involved in the initial extension of the mycolate chain and forms monounsaturated fatty acids that averaged 40 carbons in length (PubMed:12464486). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

kasA

3-oxoacyl-[acyl-carrier-protein] synthase 1

kasA

Molecular Synopsis