FEATURES

FAMILY

phosphatase 2A regulatory subunit B family

DESCRIPTION

Also known as 2ABB_RABIT, PPP2R2B. The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TOMM22 (By similarity). Interacts with IER5 (via N- and C-terminal regions) (By similarity).

EXTERNAL LINKS

PPP2R2B

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Mutations

Mutation(s) distribution

Mutations table

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