FEATURES

FAMILY

DESCRIPTION

Also known as METK1_HUMAN, MAT1A, AMS1, MATA1. Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Homotetramer (MAT-I); dimer of dimers (PubMed:23425511). Homodimer (MAT-III) (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MAT1A

S-adenosylmethionine synthase isoform type-1

Mutations

Mutation(s) distribution

Mutations table

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