FEATURES

FAMILY

DESCRIPTION

Also known as AP1_SCHPO, pap1, caf3. Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes like catalase ctt1 and components of the cellular thiol-reducing pathways, including the thioredoxin system (trx2, trr1), ABC tansporters involved in multidrug resistance like bfr1/hba2 and pmd1 as well as the gene obr1/apt1. Preferentially binds to promoters with the core binding site 5'-TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location. Oxidative stress induces nuclear accumulation and as a result pap1 transcriptional activity. Required for sty1/spc1-confered staurosporine resistance. Homodimer (PubMed:11017199). The reduced form of pap1 interacts in the nucleus with the nuclear export protein crm1, and in the cytoplasm with the peroxiredoxin tpx1 (PubMed:12100563, PubMed:24316080).

EXTERNAL LINKS

pap1

Mutations

Mutation(s) distribution

Mutations table