FEATURES

FAMILY

DESCRIPTION

Also known as ROR1_HUMAN, ROR1, NTRKR1. Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ROR1

Inactive tyrosine-protein kinase transmembrane receptor ROR1

ROR1

Molecular Synopsis