FEATURES

FAMILY

DESCRIPTION

Also known as ELP4_YEAST, ELP4, HAP1, TOT7. Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:10024884, PubMed:11296232, PubMed:11689709, PubMed:11904415, PubMed:15138274). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:18755837). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232). May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368). Component of the RNA polymerase II elongator complex, which consists of ELP1/IKI3, ELP2, ELP3, ELP4, ELP5/IKI1 and ELP6 (PubMed:11435442, PubMed:11390369, PubMed:11689709, PubMed:27974378, PubMed:27872205). The elongator complex is composed of two copies of the Elp123 subcomplex (composed of ELP1/IKI3, ELP2 and ELP3) and two copies of the Elp456 subcomplex (composed of ELP4, ELP5/IKI1 and ELP6) (PubMed:27974378, PubMed:27872205). The Elp123 subcomplex forms a two-lobed scaffold, which binds the Elp456 subcomplex asymmetrically (PubMed:27974378, PubMed:27872205). The Elp456 subcomplex binds tRNA and has ATPase activity (PubMed:22556426, PubMed:22343726). ELP4 interacts with KTI12 (PubMed:15772087).

Also known as ELP4_YEAST, ELP4, HAP1, TOT7. Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is in ...

EXTERNAL LINKS

ELP4

Structural Ligandability

Domains Chains

Distribution