FEATURES

FAMILY

DESCRIPTION

Also known as CSY2_PSEAB, csy2. CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 and Cascade participate in CRISPR interference, the third stage of CRISPR immunity (Potential). Absolutely required for crRNA production or stability. The Csy ribonucleoprotein complex binds target ssDNA with high affinity but target dsDNA with much lower affinity. Interacts directly with Csy1; part of the Csy ribonucleoprotein complex with a probable stoichiometry of Csy1(1), Csy2(1), Csy3(6), Cas6/Csy4(1)-crRNA(1). A Csy3(6), Cas6/Csy4(1)-crRNA(1) subcomplex is also formed.

EXTERNAL LINKS

csy2

CRISPR-associated protein Csy2

csy2

Molecular Synopsis