FEATURES

DESCRIPTION

Also known as ERYA2_SACER, eryA. Involved in the biosynthesis of antibiotic erythromycin via the biosynthesis of its aglycone precursor, 6-deoxyerythronolide B (6-dEB). Homodimer (PubMed:12954331, PubMed:17719492, PubMed:18952099). Erythronolide synthase is composed of EryAI, EryAII and EryAIII multimodular (2 modules) polypeptides each coding for a functional synthase subunit which participates in 2 of the six FAS-like elongation steps required for formation of the polyketide. Module 1, 2, 3, 4, 5, and 6 participating in biosynthesis steps 1, 2, 3, 4, 5, and 6, respectively.

EXTERNAL LINKS

uniprot
enzyme classification

eryA

6-deoxyerythronolide-B synthase EryA2, modules 3 and 4

Mutations

Mutation(s) distribution

Mutations table

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