FEATURES

DESCRIPTION

Also known as LCD1_YEAST, LCD1, DDC2, PIE1. Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited by the single-strand-binding protein complex RPA to DNA lesions in order to initiate the DNA repair by homologous recombination, after the MRX-complex and TEL1 are displaced. Required for the recruitment of MEC1 to DNA lesions, the activation of CHK1 and RAD53 kinases and phosphorylation of RAD9 in response to DNA damage. Required for cell growth and meiotic recombination. Forms a complex with MEC1.

EXTERNAL LINKS

uniprot
enzyme classification

LCD1

Mutations

Mutation(s) distribution

Mutations table