FEATURES

FAMILY

NAD(P)-dependent epimerase/dehydratase family

DESCRIPTION

Also known as GALE_NEIGO, galE. Involved in the metabolism of galactose. Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

galE

UDP-glucose 4-epimerase

galE

Structural Ligandability

Domains Chains

Distribution