FEATURES

FAMILY

DESCRIPTION

Also known as VP40_EBOZM, VP40. Plays an essential role virus particle assembly and budding (PubMed:16719918, PubMed:33673144). Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101 (PubMed:15892969, PubMed:16719918, PubMed:23637409, PubMed:25786915, PubMed:26753796, PubMed:27489272). The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding (PubMed:33673144). May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis) (PubMed:27872619). Homodimer (PubMed:23953110). Homohexamer (PubMed:23953110, PubMed:11118208). Homooctamer (PubMed:12919741). Exists as a dimer until it reorganizes at the plasma membrane into a hexameric form using phosphatidylinositol 4, 5-bisphosphate (PI(4, 5)P2) (PubMed:23953110, PubMed:25159197, PubMed:26753796, PubMed:29950600). Hexamers are critical for budding (PubMed:23953110). Octamers function in genome replication and RNA binding (PubMed:12919741). Interacts with host TSG101 (PubMed:12559917). As a homohexamer, interacts with the WW domain 3 of host NEDD4 (PubMed:11095724, PubMed:12559917). Interacts with the nucleoprotein/NP (PubMed:17229682, PubMed:21987757). Interacts (via YPx(n)L/I motif) with host PDCD6IP/ALIX; this interaction supports efficient egress of viral particles (PubMed:25786915). Interacts with VP35 (PubMed:16698994). Interacts with host ITCH; this interaction is required for efficient egress (PubMed:27489272). Interacts (via PPXY motif) with host SMURF2 (via WW domains); the interaction positively regulates virus budding (PubMed:33673144).

EXTERNAL LINKS

VP40

Matrix protein VP40

VP40

Molecular Synopsis