FEATURES

FAMILY

DESCRIPTION

Also known as NRG1_CHICK, NRG1, ARIA. Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses (PubMed:8453670, PubMed:9491987). Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

NRG1

Pro-neuregulin-1, membrane-bound isoform

NRG1

Structural Ligandability

Domains Chains

Distribution