FEATURES

FAMILY

U1 small nuclear ribonucleoprotein C family

DESCRIPTION

Also known as RU1C_YEAST, YHC1. Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. YHC1/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. U1 snRNP is composed of the 7 core Sm proteins SMB1, SMD1, SMD2, SMD3, SME1, SMX3 and SMX2 (Sm proteins B, D1, D2, D3, E, F and G, respectively) that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 10 U1 snRNP-specific proteins SNP1/U1-70K, MUD1/U1-A, YHC1/U1-C, LUC7, NAM8, PRP39, PRP40, PRP42, SNU56 and SNU71. YHC1/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

EXTERNAL LINKS

YHC1

U1 small nuclear ribonucleoprotein C

YHC1

Molecular Synopsis