FEATURES

DESCRIPTION

Also known as VPS38_YEAST, VPS38, VPL17. Involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through generating a specific pool of phosphatidylinositol 3-phosphate allowing the recruitment of the retromer complex proteins to the endosome). Mediates the interaction between VPS30 and the VPS34-VPS15 core complex, leading to the recruitment of VPS30 to the membrane. Component of the VPS34 PI3-kinase complex II composed of VPS15, VPS30, VPS34 and VPS38.

EXTERNAL LINKS

VPS38

Mutations

Mutation(s) distribution

Mutations table