FEATURES

DESCRIPTION

Also known as IBPA_HISS2, ibpA, p76. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific tyrosine residue of host Rho GTPases RhoA, Rac and Cdc42. The resulting AMPylation inactivates Rho GTPases, thereby inhibiting actin assembly in infected cells. Probably also acts as a cysteine protease, which may play a central role after invasion of host cell and in virulence. Possible member (with IbpB) of a 2 partner secretion. Probably able to bind bovine epithelial cells (host cells). May participate in the formation of fibrils at the surface of the bacteria. Immunoglobulin-binding protein.

EXTERNAL LINKS

uniprot
enzyme classification

ibpA

Protein adenylyltransferase and cysteine protease IbpA

ibpA

Molecular Synopsis