FEATURES

FAMILY

DESCRIPTION

Also known as CSR1_YEAST, CSR1, SFH2. Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Activates SPO14/PLD1 (phospholipase D1) by stimulating phosphoinositide synthesis via the STT4 PtdIns 4-kinase. Modulates ArfGAP function through effects on SPO14 activity. Inhibits phosphatidylcholine degradation by PLB1 (phospholipase B1). May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress. Inhibits fatty acid synthase activity in response to heme depletion and oleic acid starvation, preventing saturated fatty acid (SFA) accumulation (PubMed:17803462). Forms a complex with 2 TSA2 subunits. Binds phosphatidylinositol (PtdIns).

EXTERNAL LINKS

CSR1

Phosphatidylinositol transfer protein CSR1

Mutations

Mutation(s) distribution

Mutations table

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