FEATURES

FAMILY

DESCRIPTION

Also known as TBPB2_NEIMI, tbpB, tbp2. Neisseria acquires iron by extracting it from serum transferrin (TF) in its human host. Acts as a TF receptor and is required for TF utilization. Involved in the initial capture of TF. Helps select only those TF molecules that can be used as an iron source and concentrates them on the cell surface, maintaining the iron-loaded status of the TF C-terminal lobe until its delivery to TbpA. Binds only human holo-transferrin (TF), via the TF C-terminus. Forms a large complex with TF and TbpA (By similarity). Interacts via its C-terminal domain with Slam1 (PubMed:27572441).

EXTERNAL LINKS

uniprot
enzyme classification

tbpB

Transferrin-binding protein B

tbpB

Molecular Synopsis