FEATURES

FAMILY

DESCRIPTION

Also known as KRAF1_CAEEL, lin-45, raf-1. Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60 (PubMed:8483497, PubMed:11861555, PubMed:14724126). Required for progression of developing oocytes through the pachytene stage (PubMed:19826475). Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Positively regulates lifespan upstream of mek-2 and mpk-1 (PubMed:20624915). Interacts with cdf-1 in a zinc-dependent manner which promotes its activity.

lin-45

Structural Ligandability

Domains Chains

Distribution