FEATURES

FAMILY

DESCRIPTION

Also known as RT109_YEAST, RTT109, KAT11, KIM2, REM50. Histone chaperone-dependent acetylase that modifies 'Lys-9', 'Lys-14', 'Lys-23', 'Lys-27', and 'Lys-56' on histone H3 (H3K9Ac, H3K14Ac and H3K23Ac, H3K27Ac, and H3K56Ac) to promote nucleosome assembly, genomic stability, DNA repair and transcriptional regulation during mitotic S-phase (PubMed:31194870, PubMed:17046836, PubMed:17369253, PubMed:17320445, PubMed:17272723, PubMed:18723682, PubMed:20560668, PubMed:21256037, PubMed:29300933, PubMed:19172748). Its residue selectivity is influenced by the acetylation status of histone H3, and also the presence of histone chaperone ASF1 that shifts selectivity to 'Lys-56' when H3K14Ac is already present (PubMed:31194870). H3K56 acetylation weakens the interaction between the histone core and the surrounding DNA in the nucleosomal particle and drives chromatin disassembly (PubMed:18577595). Autoacetylates (PubMed:18568037, PubMed:18707894, PubMed:18719104). Independently of acetyltransferase activity, stimulates histone deposition by VPS75 (PubMed:19172748). Involved in regulation of Ty1 transposition (PubMed:11779788). Forms a complex composed of two RTT109 subunits and one VPS75 homodimer; each RTT109 subunit interacts predominantly with VPS75 instead of interacting with the other RTT109 subunit (PubMed:21256037, PubMed:20560668, PubMed:17320445, PubMed:31387991, PubMed:18719104). Interacts with VPS75; the interaction is direct (PubMed:31387991, PubMed:20560668, PubMed:17369253, PubMed:17690098, PubMed:17320445, PubMed:17272723, PubMed:18723682, PubMed:18719104, PubMed:21256037). Interacts (via C-terminus) with ASF1; the interaction is direct (PubMed:29300933, PubMed:31387991, PubMed:17690098, PubMed:17320445). Interacts with histone H3/H4 heterodimers via histone H3 (PubMed:21454705, PubMed:19172748).

Also known as RT109_YEAST, RTT109, KAT11, KIM2, REM50. Histone chaperone-dependent acetylase that modifies 'Lys-9', 'Lys-14', 'Lys-23', 'Lys-27', and 'Lys-56' on histone H3 (H3K9Ac, H3K14Ac a ...

EXTERNAL LINKS

RTT109

Histone acetyltransferase RTT109

RTT109

Molecular Synopsis