FEATURES

FAMILY

DESCRIPTION

Also known as VE6_HPV04, E6. Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response. Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity. Interacts with host BAK1.

EXTERNAL LINKS

uniprot
enzyme classification

E6

Protein E6

E6

Structural Ligandability

Domains Chains

Distribution