FEATURES

FAMILY

DESCRIPTION

Also known as PHACB_EMEND, phacB, pshA. Catalyzes the hydroxylation of 3-hydroxyphenylacetate and 3, 4-dihydroxyphenylacetate to 2, 5-dihydroxyphenylacetate (homogentisate) and 2, 4, 5-trihydroxyphenylacetate, respectively. Both of these compounds are used as substrate by homogentisate dioxygenase in the homogentisate pathway. The homogentisate pathway is used to catabolize phenylacetate and use it as a carbon source. Can also catalyze the hydroxylation of phenylacetate to 2-hydroxyphenylacetate at low efficiency to compensate for loss of phacA.

EXTERNAL LINKS

uniprot
enzyme classification

phacB

3-hydroxyphenylacetate 6-hydroxylase

phacB

Molecular Synopsis