FEATURES

FAMILY

DESCRIPTION

Also known as RASK_MONDO, KRAS. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation (PubMed:8312604). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity). Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (when farnesylated) with PDE6D; this promotes dissociation from the cell membrane (By similarity). Interacts with SOS1 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

KRAS

GTPase KRas

KRAS

Structural Ligandability

Domains Chains

Distribution