FEATURES

FAMILY

DESCRIPTION

Also known as TGM3_HUMAN, TGM3. Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. Consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide.

EXTERNAL LINKS

TGM3

Protein-glutamine gamma-glutamyltransferase E

TGM3

Molecular Synopsis