FEATURES

FAMILY

DESCRIPTION

Also known as I10R2_HUMAN, IL10RB, CRFB4, D21S58, D21S66. Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Heterodimer with IFNLR1.

Also known as I10R2_HUMAN, IL10RB, CRFB4, D21S58, D21S66. Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10 ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IL10RB

Interleukin-10 receptor subunit beta

IL10RB

Molecular Synopsis