FEATURES

FAMILY

class-I pyridoxal-phosphate-dependent aminotransferase family

DESCRIPTION

Also known as KAT1_RAT, Kyat1, Ccbl1, Kat. Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:7796908, PubMed:6783036, PubMed:2072101). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:8502223). Homodimer.

EXTERNAL LINKS

Kyat1

Kynurenine--oxoglutarate transaminase 1

Kyat1

Molecular Synopsis