FEATURES

FAMILY

DESCRIPTION

Also known as CSK22_ARATH, CKA2. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity). The alpha chain contains the catalytic site. The tetrameric holoenzyme CK2, composed of two alpha and two beta subunits, phosphorylates the transcription factor PIF1 after an exposure to light, resulting in a proteasome-dependent degradation of PIF1 and promotion of photomorphogenesis (PubMed:21330376). CK2 phosphorylates translation initiation factors. May participate in the regulation of the initiation of translation (PubMed:19509278). Acts as circadian clock component that maintains the correct period length through phosphorylation of CCA1 (PubMed:21900482). May act as an ectokinase that phosphorylates several extracellular proteins. Heterotetramer of two catalytic alpha subunits and two regulatory beta subunits.

CKA2

Structural Ligandability

Domains Chains

Distribution