FEATURES

FAMILY

protein prenyltransferase subunit alpha family

DESCRIPTION

Also known as PGTA_RAT, Rabggta, Ggta. Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding (PubMed:11675392, PubMed:10745007, PubMed:12620235, PubMed:18399557, PubMed:18756270, PubMed:19894725, PubMed:21520375, PubMed:22963166, PubMed:8505342). The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp) (PubMed:12620235). The CHM:RGGT:Rab complex is destabilized by GGpp (PubMed:12620235). Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction (By similarity).

EXTERNAL LINKS

Rabggta

Mutations

Mutation(s) distribution

Mutations table