FEATURES

FAMILY

DESCRIPTION

Also known as P4K2A_XENLA, pi4k2a. Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4, 5-bisphosphate (PIP2), a precursor of the second messenger inositol 1, 4, 5-trisphosphate (InsP3).

EXTERNAL LINKS

uniprot
enzyme classification

pi4k2a

Phosphatidylinositol 4-kinase type 2-alpha

pi4k2a

Molecular Synopsis