FEATURES

FAMILY

DESCRIPTION

Also known as CNOT7_DANRE, cnot7, caf1. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity). Component of the CCR4-NOT complex.

cnot7

Structural Ligandability

Domains Chains

Distribution