FEATURES

FAMILY

DESCRIPTION

Also known as GCNT1_MOUSE, Gcnt1. Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. Interacts with GOLPH3; may control GCNT1 retention in the Golgi.

EXTERNAL LINKS

uniprot
enzyme classification

Gcnt1

Beta-1, 3-galactosyl-O-glycosyl-glycoprotein beta-1, 6-N-acetylglucosaminyltransferase

Gcnt1

Molecular Synopsis