tdo-2 (Tryptophan 2,3-dioxygenase)
FEATURES
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ORGANISM
Caenorhabditis elegans
FAMILY
DESCRIPTION
Also known as T23O_CAEEL, tdo-2. Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine (PubMed:27995966). Catalyzes the oxidative cleavage of the indole moiety (PubMed:27995966). Involved in regulation of protein homeostasis, longevity and reproducive life span (PubMed:22927396, PubMed:27995966). Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha-synuclein, via its effects on tryptophan metabolism (PubMed:22927396). Homotetramer. Dimer of dimers.
Also known as T23O_CAEEL, tdo-2. Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine (PubMed:27995966). Catalyzes the oxidative cleavage of the indole moiety (PubMed:27995966). Involved in regulation of protein homeostasis, longevity and reprodu
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tdo-2

Tryptophan 2,3-dioxygenase

Molecular Synopsis