FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as LE767_CAEEL, let-767, dhs-10. Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids (PubMed:12905072, PubMed:18390550, PubMed:21926990). Probably involved in hormone production as it metabolizes 4-androstendione (androst-4-ene-3, 17-dione) into testosterone and estrone into estradiol (17beta-estradiol) in vitro, but the physiological steroid substrate is unknown (PubMed:17951538).

EXTERNAL LINKS

uniprot
enzyme classification

let-767

Very-long-chain 3-oxooacyl-coA reductase let-767

let-767

Structural Ligandability

Domains Chains

Distribution