FEATURES

FAMILY

DESCRIPTION

Also known as PGLK_CAMJE, pglK, wlaB. Mediates the ATP-dependent translocation of the undecaprenylpyrophosphate-linked heptasaccharide intermediate across the cell membrane; this is an essential step during the N-linked protein glycosylation pathway. Transport across the membrane is effected via ATP-driven conformation changes. Most likely, only the polar and charged part of the glycolipid enter the substrate-binding cavity, and the lipid tail remains exposed to the membrane lipids during the transmembrane flipping process. Homodimer; domain-swapped. Helices that arise in transmembrane regions 4 and 5 from one subunit cross over and contact the nucleotide-binding domain from the other subunit.

EXTERNAL LINKS

pglK

Protein glycosylation K

pglK

Molecular Synopsis