FEATURES

FAMILY

DESCRIPTION

Also known as TOF1_PHANO, TOF1. Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.

EXTERNAL LINKS

uniprot
enzyme classification

TOF1

Topoisomerase 1-associated factor 1

TOF1

Structural Ligandability

Domains Chains

Distribution