FEATURES

FAMILY

DESCRIPTION

Also known as MRP_BOVIN, MARCKSL1. Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status. Interacts with calmodulin.

EXTERNAL LINKS

uniprot
enzyme classification

MARCKSL1

MARCKS-related protein

MARCKSL1

Structural Ligandability

Domains Chains

Distribution