FEATURES

FAMILY

DESCRIPTION

Also known as METL9_BOVIN, METTL9. Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins. Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins. Constitutes the main methyltransferase for the 1-methylhistidine modification in cell.

EXTERNAL LINKS

uniprot
enzyme classification

METTL9

Protein-L-histidine N-pros-methyltransferase

METTL9

Molecular Synopsis